Croker, DM,Davey, RJ,Rasmuson, AC,Seaton, CC

2013

January

Crystengcomm

Solution mediated phase transformations between co-crystals

Published

()

L-GLUTAMIC ACID POLYMORPHIC TRANSFORMATION SECONDARY NUCLEATION COCRYSTAL ENHANCEMENT CHEMISTRY FORM

15

2044

2047

A solution mediated transformation between two co-crystal phases has been observed for the p-toluensulfonamide-triphenylphosphine oxide co-crystal system. This system has two known co-crystals with 1 : 1 and 3 : 2 stoichiometry respectively, and the ternary phase diagram (TPD) for the system has been determined in acetonitrile previously. By manipulating the solution composition in this solvent to a region of the TPD where the 1 : 1 co-crystal is stable, the 3 : 2 co-crystal could be observed to convert to the 1 : 1 co-crystal. The corresponding transformation was true for the 1 : 1 co-crystal in a region of the TPD where the 3 : 2 co-crystal is stable; the 1 : 1 co-crystal converted to the 3 : 2 co-crystal.

DOI 10.1039/c2ce26801a