Croker, DM,Hennigan, MC,Maher, A,Hu, Y,Ryder, AG,Hodnett, BK

2012

January

Journal Of Pharmaceutical And Biomedical Analysis

A comparative study of the use of powder X-ray diffraction, Raman and near infrared spectroscopy for quantification of binary polymorphic mixtures of piracetam

Published

()

Piracetam polymorphs Quantitative analysis Powder X-ray diffraction Raman spectroscopy Near-infrared spectroscopy SOLID-STATE FORMS QUANTITATIVE-ANALYSIS RANITIDINE HYDROCHLORIDE TERNARY MIXTURES PHARMACEUTICAL SOLIDS TABLETS CRYSTALLIZATION DIFFRACTOMETRY SULFATHIAZOLE DIHYDRATE

63

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Diffraction and spectroscopic methods were evaluated for quantitative analysis of binary powder mixtures of FII(6.403) and FIII(6.525) piracetam. The two polymorphs of piracetam could be distinguished using powder X-ray diffraction (PXRD), Raman and near-infrared (NIR) spectroscopy. The results demonstrated that Raman and NIR spectroscopy are most suitable for quantitative analysis of this polymorphic mixture. When the spectra are treated with the combination of multiplicative scatter correction (MSC) and second derivative data pretreatments, the partial least squared (PLS) regression model gave a root mean square error of calibration (RMSEC) of 0.94 and 0.99%, respectively. FIII(6.525) demonstrated some preferred orientation in PXRD analysis, making PXRD the least preferred method of quantification. (C) 2012 Elsevier B.V. All rights reserved.

10.1016/j.jpba.2012.01.013